Evaluation of neurotoxicity potential in rats: the functional observational battery

This unit describes the functional observational battery (FOB), a behavioral screening procedure commonly used in safety pharmacology and toxicology studies to assess potentially adverse effects of test agents on the central nervous system. The battery includes general observations and the determina...

Full description

Saved in:
Bibliographic Details
Published inCurrent protocols in pharmacology Vol. Chapter 10; p. Unit 10.12
Main Authors Boucard, Aurélie, Bétat, Anne-Marie, Forster, Roy, Simonnard, Alain, Froget, Guillaume
Format Journal Article
LanguageEnglish
Published United States 01.12.2010
Subjects
Animals
Behavior, Animal - drug effects
Biomedical Research
Central Nervous System - drug effects
Drug Evaluation, Preclinical - methods
Female
Male
Neurons - drug effects
Neurotoxicity Syndromes - diagnosis
Neurotoxicity Syndromes - physiopathology
Neurotoxicity Syndromes - prevention & control
Rats
Research Design
Severity of Illness Index
Online AccessGet more information

Cover

More Information
Summary:This unit describes the functional observational battery (FOB), a behavioral screening procedure commonly used in safety pharmacology and toxicology studies to assess potentially adverse effects of test agents on the central nervous system. The battery includes general observations and the determination of reactivity to various stimuli. Also presented is the severity score index for analyzing individual measurements and evaluations over a range of endpoints. The severity score index can be used to identify, quantify, and describe the effects of compounds on neurological, autonomic, and behavioral functions.
ISSN:1934-8290
DOI:10.1002/0471141755.ph1012s51