Bioequivalency of ranitidine tablets

The bioavailability of two brands of ranitidine tablets was studied in 10 healthy volunteers. Formulation factors were compared by performing disintegration, dissolution and content uniformity tests. Plasma concentrations of ranitidine were measured using a sensitive and precise high pressure liquid...

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Bibliographic Details
Published inJournal of clinical pharmacy and therapeutics Vol. 14; no. 2; p. 111
Main Authors Alkaysi, H N, Salem, M A, Gharaibeh, A M, el-Sayed, Y M, Ali-Gharaibeh, K I, Badwan, A A
Format Journal Article
LanguageEnglish
Published England 01.04.1989
Subjects
Adult
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid
Humans
Male
Ranitidine - administration & dosage
Ranitidine - pharmacokinetics
Solubility
Tablets
Therapeutic Equivalency
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Summary:The bioavailability of two brands of ranitidine tablets was studied in 10 healthy volunteers. Formulation factors were compared by performing disintegration, dissolution and content uniformity tests. Plasma concentrations of ranitidine were measured using a sensitive and precise high pressure liquid chromatographic (HPLC) procedure. Pharmacokinetic parameters were determined for both formulations and included: Cmax, AUCt, AUC infinity, tmax, t1/2 and the terminal rate of elimination (k). Statistical analysis revealed that differences between the brands were not significant. The two formulations can be considered to be bioequivalent.
ISSN:0269-4727
DOI:10.1111/j.1365-2710.1989.tb00229.x