Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

• Published in: Advanced science Vol. 9; no. 27; pp. e2202684 - n/a
• Main Authors: Li, Yue, Miao, Yong, Yang, Lunan, Zhao, Yitao, Wu, Keke, Lu, Zhihui, Hu, Zhiqi, Guo, Jinshan
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.09.2022
• Subjects: Acids; Anti-Bacterial Agents - pharmacology; Anti-Infective Agents - pharmacology; Anti-Inflammatory Agents; Antibiotics; antimicrobial; Antimicrobial agents; Antioxidants - pharmacology; Bacteria; Bacterial infections; Binding sites; Biocompatible Materials; Biomedical materials; coating; Drug resistance; E coli; Enzymes; Flavonoids; Humans; Hydrogels; Ligands; medical device modification; Medical equipment; Metals; metal–phenolic networks (MPNs); Microorganisms; Nanoparticles; Orthopedics; Permeability; Phenols; Polyphenols; Staphylococcus infections; wound healing; United States > US; antimicrobial; wound healing; coating; medical device modification; metal-phenolic networks (MPNs)
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.202202684

Due to the abuse of antibiotics and the emergence of multidrug resistant microorganisms, medical devices, and related biomaterials are at high risk of microbial infection during use, placing a heavy burden on patients and healthcare systems. Metal–phenolic networks (MPNs), an emerging organic–inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti‐inflammatory, antioxidant, and antibacterial properties by making use of the coordination between phenolic ligands and metal ions. Further, MPNs have received widespread attention in antimicrobial infections due to their facile synthesis process, excellent biocompatibility, and excellent antimicrobial properties brought about by polyphenols and metal ions. In this review, different categories of biomaterials based on MPNs (nanoparticles, coatings, capsules, hydrogels) and their fabrication strategies are summarized, and recent research advances in their antimicrobial applications in biomedical fields (e.g., skin repair, bone regeneration, medical devices, etc.) are highlighted. This review discusses the outstanding antibacterial performance of metal–phenolic networks (MPNs) as biomaterials in recent years. The main components of MPNs and different forms of MPNs biomaterials are mainly introduced, and the antibacterial applications of MPNs‐based biomaterials in skin repair, bone regeneration, biodevices, and other fields are summarized.