Phenytoin-Induced Gingival Overgrowth : A Review of the Molecular, Immune, and Inflammatory Features

Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, wit...

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Published inISRN dentistry Vol. 2011; no. 2011; pp. 1 - 8
Main Authors Corrêa, Jôice Dias, Queiroz-Junior, Celso Martins, Costa, José Eustáquio, Teixeira, Antônio Lúcio, Silva, Tarcilia Aparecida
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Puplishing Corporation 01.01.2011
International Scholarly Research Network
Hindawi Limited
Subjects
Anticonvulsants
Collagen
Drug dosages
Pathogenesis
Review
Substance abuse treatment
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Summary:Gingival overgrowth (GO) is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. GO is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components, with varying degrees of inflammation. One of the main drugs associated with GO is the antiepileptic phenytoin, which affects gingival tissues by altering extracellular matrix metabolism. Nevertheless, the pathogenesis of such drug-induced GO remains fulfilled by some contradictory findings. This paper aims to present the most relevant studies regarding the molecular, immune, and inflammatory aspects of phenytoin-induced gingival overgrowth.
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Academic Editors: M. Del Fabbro and S. E. Widmalm
ISSN:2090-4371
2090-438X
DOI:10.5402/2011/497850