Evaluation of Substituted Pyrazole-Based Kinase Inhibitors in One Decade (2011-2020): Current Status and Future Prospects

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 1; p. 330
• Main Authors: El-Gamal, Mohammed I, Zaraei, Seyed-Omar, Madkour, Moustafa M, Anbar, Hanan S
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.01.2022; MDPI
• Subjects: anti-inflammatory; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; anticancer; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis; Apoptosis - drug effects; Binding sites; Biological activity; Biomarkers, Tumor; Breast cancer; Cancer; Cell cycle; Cervical cancer; Cervix; Chemical compounds; Crystal structure; Drug Development - history; Drug Development - methods; Drug Development - trends; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - classification; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - therapeutic use; History, 21st Century; Humans; Hydrogen bonds; Immune Checkpoint Inhibitors - chemistry; Immune Checkpoint Inhibitors - pharmacology; Inhibitors; kinase inhibitor; Kinases; Lymphoma; Melanoma; Metabolism; Models, Molecular; neurodegenerative disorders; Pharmacology; Phosphorylation; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - pharmacology; Protein Kinase Inhibitors - therapeutic use; Proteins; Pyrazole; Pyrazoles; Pyrazoles - chemistry; Pyrazoles - pharmacology; Pyrazoles - therapeutic use; Review; Reviews; Signal Transduction - drug effects; Structure-Activity Relationship; anti-inflammatory; pyrazole; kinase inhibitor; neurodegenerative disorders; anticancer
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27010330

Pyrazole has been recognized as a pharmacologically important privileged scaffold whose derivatives produce almost all types of pharmacological activities and have attracted much attention in the last decades. Of the various pyrazole derivatives reported as potential therapeutic agents, this article focuses on pyrazole-based kinase inhibitors. Pyrazole-possessing kinase inhibitors play a crucial role in various disease areas, especially in many cancer types such as lymphoma, breast cancer, melanoma, cervical cancer, and others in addition to inflammation and neurodegenerative disorders. In this article, we reviewed the structural and biological characteristics of the pyrazole derivatives recently reported as kinase inhibitors and classified them according to their target kinases in a chronological order. We reviewed the reports including pyrazole derivatives as kinase inhibitors published during the past decade (2011-2020).