Fabrication and Characterization of Marine Polysaccharides Hemostatic Dressing

• Published in: IOP conference series. Materials Science and Engineering Vol. 423; no. 1; pp. 12172 - 12178
• Main Authors: Zhong, Qing-Kun, Hu, Zhang, Zhang, Dong-Ying, Li, Si-Dong
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.10.2018
• Subjects: Calcium chloride; Chitosan; Coagulation; Crosslinking; Fourier transforms; Infrared spectroscopy; Morphology; Performance evaluation; Polysaccharides; Raw materials; Response surface methodology; Sodium alginate; Swelling ratio
• ISSN: 1757-8981; 1757-899X; 1757-899X
• DOI: 10.1088/1757-899X/423/1/012172

Marine polysaccharides composite hemostatic dressing was fabricated with calcium chloride as the crosslinking agent and carboxymethyl chitosan/sodium alginate as raw materials. On the basis of the pre-experiment, the fabrication process of marine polysaccharides hemostatic dressing was optimized by response surface methodology. The dressing prepared under the optimum conditions was characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), and then its hemostatic performance was evaluated. The results showed that the optimum conditions for the preparation of hemostatic dressing were as follows: concentration of CMCS is 0.5%, mass ratio of CMCS and SA is 1: 2.5, concentration of CaCl2 is 1.5%. And the swelling ratio of the dressing reached 8020%. FTIR showed that the crosslinking between carboxymethyl chitosan and sodium alginate was successful. Morphology observation found that the appearance was smooth, the pores were large and uniform. Furthermore, the dressing had good coagulation performance.