Outcomes of basal ganglia and thalamic cavernous malformation surgery: A meta-analysis

• Published in: Journal of clinical neuroscience Vol. 73; pp. 209 - 214
• Main Authors: Kearns, Kathryn N., Chen, Ching-Jen, Tvrdik, Petr, Park, Min S., Kalani, M. Yashar S.
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01.03.2020
• Subjects: Basal ganglia; Cavernous malformation; Morbidity; Mortality; Outcome; Surgery; Thalamus; Cavernous malformation; Basal ganglia; Mortality; Outcome; Surgery; Thalamus; Morbidity
• ISSN: 0967-5868; 1532-2653; 1532-2653
• DOI: 10.1016/j.jocn.2019.12.019

•Deep-seated cavernous malformation surgery has high cure rates with low morbidity.•Most patients exhibited improved or stable neurological function at final follow-up.•Cavernous malformations should be completely resected to avoid future hemorrhage. Surgical resection of basal ganglia (BG) and thalamic cavernous malformations (CMs) has not yet become standardized in the field of neurosurgery due to the eloquent location of these lesions and the relative paucity of literature on the subject. This review presents a consolidation of the available literature on outcomes and complication rates after surgical resection of these lesions. A systematic literature review was performed via PubMed database for articles published between 1985 and 2019. Studies comprising ≥2 patients receiving surgery for BG or thalamic CMs with available follow-up data were included. Pooled data included patient demographics, CM preoperative characteristics, and surgical outcomes Twenty studies comprising 227 patients were included for analysis. Complete resection was achieved in 94.7% (fixed-effects pooled estimate [FE]: 94.9%[91.0%–97.8%]; random-effects pooled estimate [RE]: 90.0%[79.8%–96.9%]), and hemorrhage of incompletely resected CMs occurred in 50% (FE: 55.9%[25.9%–83.6%]; RE: 55.9%[25.9%–83.6%]) of patients. Early morbidity was observed in 24.0% (FE: 24.9%[17.8%–32.6%]; RE: 24.9%[17.8%–32.6%]). At final follow-up, 67.3% (FE: 67.7%[58.8%–76.0%]; RE: 67.8%[52.2%–81.6%]) and 20.6% (FE: 20.6%[13.6%–28.6%]; RE: 20.9%[9.8%–34.9%]) had improvement and stability of preoperative symptoms, respectively. Mortality rate was 1.3% (FE: 2.3%[0.6%–5.1%]; RE: 2.3%[0.6%–5.1%]). Therefore, high cure rates with low rates of postoperative morbidity can be achieved in BG or thalamic CM surgery. Most patients had improved neurological function at final follow-up. Complete resection should be attempted to reduce rates of repeat hemorrhage.