New delivery systems for brain tumor therapy

Therapy of brain tumors has been limited by lack of effective methods of drug delivery. Systemic administration often fails to achieve therapeutic concentrations of drugs within intracranial tumors despite toxic systemic levels. This article discusses new methods for delivering therapeutic agents to...

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Bibliographic Details
Published inNeurologic clinics Vol. 13; no. 4; p. 813
Main Authors Sipos, E P, Brem, H
Format Journal Article
LanguageEnglish
Published United States 01.11.1995
Subjects
Adult
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Brain Neoplasms - drug therapy
Brain Neoplasms - mortality
Brain Neoplasms - radiotherapy
Brain Neoplasms - surgery
Carmustine - administration & dosage
Carmustine - adverse effects
Chemotherapy, Adjuvant
Combined Modality Therapy
Drug Administration Routes
Drug Implants
Humans
Survival Rate
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Summary:Therapy of brain tumors has been limited by lack of effective methods of drug delivery. Systemic administration often fails to achieve therapeutic concentrations of drugs within intracranial tumors despite toxic systemic levels. This article discusses new methods for delivering therapeutic agents to brain tumors, including intra-arterial, intrathecal, intraventricular, and interstitial administration techniques.
ISSN:0733-8619
DOI:10.1016/S0733-8619(18)30019-7