Frailty and cognitive decline

Frailty and cognitive impairment are among the 2 most common geriatric syndromes. Their presence poses major risks to the elderly including greater disability, reduced quality of life, and higher morbi-mortality. Recent evidence suggest that frailty can be a risk factor for incident dementia. The op...

Full description

Saved in:
Bibliographic Details
Published inTranslational research : the journal of laboratory and clinical medicine Vol. 221; pp. 58 - 64
Main Authors Fabrício, Daiene de Morais, Chagas, Marcos Hortes N., Diniz, Breno S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2020
Subjects
CRP
HPA
AD
ROS
Online AccessGet full text

Cover

More Information
Summary:Frailty and cognitive impairment are among the 2 most common geriatric syndromes. Their presence poses major risks to the elderly including greater disability, reduced quality of life, and higher morbi-mortality. Recent evidence suggest that frailty can be a risk factor for incident dementia. The opposite is also true since subjects with Alzheimer's disease and other dementia also present with more severe frailty measures. The mechanisms for the association between frailty and cognitive impairment is not clear, but possibly involves abnormalities in biological processes related to aging. Here, we will review the current evidence of the association between frailty and cognitive impairment. We will also review the possible biological mechanistic links between the 2 conditions. Finally, we will address potential therapeutic targets and interventions that can mitigate both conditions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1931-5244
1878-1810
1878-1810
DOI:10.1016/j.trsl.2020.01.002