Gastric signet-ring cell adenocarcinoma masquerading as sarcoidosis

Skin examination of the trunk revealed erythematous infiltrated plaques with lupoid appearance at diascopy (figure, A), hypertrophy of sublingual salivary glands, dry syndrome, and moderate to intense bone pain, consistent with skin sarcoidosis. Laboratory tests showed polyclonal gamma-globulin elev...

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Published inThe lancet oncology Vol. 25; no. 4; p. e173
Main Authors Belkaïd, Samy, Crumbach, Laura, de Bernardi, Axel, Darnis, Sophie, Bouquerel, Margot, Neuhart, Anne, Assaad, Souad, Amini-Adle, Mona
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2024
Elsevier Limited
Subjects
Adenocarcinoma
Angiotensin
Antigens
Biopsy
C-reactive protein
Cancer
Carcinoembryonic antigen
Erythrocyte sedimentation rate
Globulins
Histology
Hypertrophy
L-Lactate dehydrogenase
Lymphatic system
Metastasis
Peptidyl-dipeptidase A
Salivary gland
Sarcoidosis
Skin tests
Supervision
Writing
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Summary:Skin examination of the trunk revealed erythematous infiltrated plaques with lupoid appearance at diascopy (figure, A), hypertrophy of sublingual salivary glands, dry syndrome, and moderate to intense bone pain, consistent with skin sarcoidosis. Laboratory tests showed polyclonal gamma-globulin elevation (15·8 g/L) with no other abnormalities, including erythrocyte sedimentation rate, C-reactive protein, angiotensin-converting enzyme, lactate dehydrogenase, carcinoembryonic antigen, and CA 15-3 antigen. Patient management requires multidisciplinary approaches with dermatologists, internists, oncologists, and anatomopathologists to enable accurate definitive diagnosis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1470-2045
1474-5488
DOI:10.1016/S1470-2045(24)00105-0