Effect of nifedipine on gastric emptying and gastrointestinal motility in man

• Published in: Digestive diseases and sciences Vol. 33; no. 5; p. 535
• Main Authors: Santander, R, Mena, I, Gramisu, M, Valenzuela, J E
• Format: Journal Article
• Language: English
• Published: United States 01.05.1988
• Subjects: Adult; Gastric Emptying - drug effects; Gastrointestinal Motility - drug effects; Humans; Male; Manometry; Nifedipine - pharmacology; Organometallic Compounds; Pentetic Acid; Technetium Tc 99m Pentetate
• ISSN: 0163-2116
• DOI: 10.1007/bf01798353

Nifedipine, a calcium-blocking agent, inhibits smooth muscle contractions in various organs including gastric muscle in vitro. Despite this, nifedipine has been found to have no effect on gastric emptying in man. We have investigated the effect of nifedipine on gastric emptying of liquids and solids and on gastrointestinal motility in six healthy subjects. For this, isotopic techniques and manometric methods were used. We confirm that nifedipine 30 mg per os does not modify gastric emptying of liquids or solids. By contrast, antral motility was significantly inhibited (P less than 0.05) and duodenal motility increased. These results could be interpreted as (1) gastroduodenal motility changes are not severe enough to alter emptying or (2) isotopic techniques are not sensitive enough to detect subtle changes in gastric emptying.