Vitamin D Levels in Children With Recurrent Aphthous Stomatitis

• Published in: Ear, nose, & throat journal Vol. 99; no. 7; pp. 460 - 463
• Main Authors: Nalbantoğlu, Burçin, Nalbantoğlu, Ayşin
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.08.2020; SAGE PUBLICATIONS, INC
• Subjects: Case-Control Studies; Child; Child, Preschool; Female; Humans; Inflammation; Male; Nutritional Status; Oral diseases; Pediatrics; Recurrence; Retrospective Studies; Stomatitis, Aphthous - blood; Stomatitis, Aphthous - etiology; Ulcers; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; oral diseases; recurrent aphthous stomatitis; children; vitamin D
• ISSN: 0145-5613; 1942-7522
• DOI: 10.1177/0145561319882783

Background: Recurrent aphthous stomatitis is one of the most prevalent oral mucosa diseases and the etiology is unclear. As a potent anti-inflammatory and immunomodulating agent, vitamin D can significantly affect oral cavity homeostasis. However, to the best of our knowledge, no study has been conducted in pediatric population on the potential role of vitamin D in recurrent aphthous stomatitis to date. The aim of the present study is to determine the vitamin D status in recurrent aphthous stomatitis in children. Methods: This study is conducted retrospectively. Seventy-two patients with minor recurrent aphthous stomatitis and 70 age-matched healthy controls included in the study. 25-Hydroxyvitamin D levels were measured in all patients using enzyme immunoassay. Results: Serum vitamin D levels were 16.4 (8.6) ng/mL in patient group and 23.1 (11.5) ng/mL in healthy controls. There was a statistically significant difference between the groups in terms of serum vitamin D levels (P = .002). There was no significant correlation between serum vitamin D levels and the severity of the recurrent aphthous stomatitis (r = 0.54, P = .76). Conclusions: Our study showed a significant difference in vitamin D levels between patients with recurrent aphthous stomatitis and the healthy control group. We also found no correlation between vitamin D status and the severity of the disease.