HIV-1 elite controllers: an immunovirological review and clinical perspectives

HIV type 1 (HIV-1) elite controllers (ECs) represent a rare group of individuals with an ability to maintain an undetectable HIV-1 viral load overtime in the absence of previous antiretroviral therapy. The mechanisms associated with this paradigm remain not clearly defined. However, loss of virologi...

Full description

Saved in:
Bibliographic Details
Published inJournal of Virus Eradication Vol. 5; no. 3; pp. 163 - 166
Main Authors Gebara, Nour Y, El Kamari, Vanessa, Rizk, Nesrine
Format Journal Article
LanguageEnglish
Published England Mediscript Ltd 18.09.2019
Elsevier
Subjects
Review
Online AccessGet full text

Cover

More Information
Summary:HIV type 1 (HIV-1) elite controllers (ECs) represent a rare group of individuals with an ability to maintain an undetectable HIV-1 viral load overtime in the absence of previous antiretroviral therapy. The mechanisms associated with this paradigm remain not clearly defined. However, loss of virological control, morbidity and mortality persist in these individuals, such as progress to AIDS-defining conditions together with persistent high rate of immune activation. Further insight into potential therapeutic options is therefore warranted. In this review, we discuss recent data on the type of immune responses understood to be associated with chronic virological control, the potential for disease progression and therapeutic options in ECs.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:2055-6640
2055-6659
DOI:10.1016/S2055-6640(20)30046-7