Divergent effects of desferrioxamine on bacterial growth and characteristics

• Published in: Journal of antibiotics Vol. 66; no. 4; pp. 199 - 203
• Main Authors: Eto, Daisei, Watanabe, Kenta, Saeki, Hisafumi, Oinuma, Ken-ichi, Otani, Ko-ichi, Nobukuni, Megumi, Shiratori-Takano, Hatsumi, Takano, Hideaki, Beppu, Teruhiko, Ueda, Kenji
• Format: Journal Article
• Language: English
• Published: Japan Nature Publishing Group 01.04.2013
• Subjects: Bacteria - drug effects; Bacteria - genetics; Bacteria - growth & development; Bacteria - ultrastructure; Culture Media; Deferoxamine - pharmacology; Microscopy, Electron, Scanning; Phenotype; Phylogeny; RNA, Ribosomal, 16S - genetics; Soil Microbiology; Streptomyces griseus - metabolism
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/ja.2012.111

Desferrioxamines (DF's) are siderophores produced by some groups of bacteria. Previously, we discovered that DFE, produced by Streptomyces griseus, induced divergent developmental phenotypes in various Streptomyces isolates. In this study, we isolated bacteria whose phenotype was affected by the presence of 0.1 mM DFB from soil samples, and studied their phylogenetic position via 16 S rRNA gene-based analysis. Isolates belonging to Microbacterium grew only in the presence of DFB in the medium. DFB promoted growth of some isolates, while significantly inhibiting that of other divergent bacteria. Different groups of isolates were affected, not because of growth-related changes, but because of changes in the colony morphology based on possible stimulation of motility. An isolate affiliated with Janthinobacterium was stimulated for violacein production as well as for pilus formation. The wide and divergent effects of DFB suggest that availability of siderophores significantly affect the structure of microbial community.