Heart Fatty Acid Binding Protein (H-FABP) as a Diagnostic Biomarker in Patients with Acute Coronary Syndrome

• Published in: Heart, lung & circulation Vol. 19; no. 11; pp. 660 - 664
• Main Authors: Gururajan, Priya, MSc, Gurumurthy, Prema, PhD, DSc, FIABMS, FIMSA, Nayar, Pradeep, MD, DNB(Card), MNAMS, FAIMS, FACC, FSCAI, Srinivasa Nageswara Rao, G., MSc, Babu, Sai, MBBS, DCP, Cherian, K.M., MS, FRACS, DSc (Hon), DSc (HC)
• Format: Journal Article
• Language: English
• Published: Australia Elsevier B.V 01.11.2010
• Subjects: Acute coronary syndrome; Acute Coronary Syndrome - blood; Acute Coronary Syndrome - diagnosis; Adult; Aged; Biomarker; Biomarkers - blood; Cardiovascular; Early Diagnosis; Electrocardiography; Fatty Acid Binding Protein 3; Fatty Acid-Binding Proteins - blood; Female; H-FABP; Humans; Male; Middle Aged; Myocardial Infarction - blood; Myocardial ischaemia; ROC; Sensitivity and Specificity; Statistics, Nonparametric; Troponin I - blood; Myocardial ischaemia; H-FABP; Biomarker; Acute coronary syndrome; ROC
• ISSN: 1443-9506; 1444-2892
• DOI: 10.1016/j.hlc.2010.06.665

Aims and objectives Diagnosis of myocardial ischaemia at an early stage in the emergency department is often difficult. A recently proposed biomarker, heart fatty acid binding protein (H-FABP) has been found to appear in the circulation superior to that of cardiac troponins in the early hours of acute coronary syndrome. We proposed to evaluate the levels of H-FABP and ascertain its utility as an early biomarker for acute coronary syndrome (ACS). Methods and results The present study was carried out in 485 subjects, of whom 297 were diagnosed as patients with ACS, 89 were diagnosed as non-cardiac chest pain (NCCP) and 99 people served as healthy controls. H-FABP levels were measured in comparison with standard markers such as troponin I and CK-MB in all subjects enrolled in the study. The levels of H-FABP were significantly raised in patients when compared to controls and NCCP ( P < 0.001). Receiver Operator Characteristic Curve (ROC) analysis showed H-FABP to be a good discriminator between patients with ischaemic heart disease and patients without ischaemic heart disease. The area under the curve was found to be 0.965 with 95% CI (0.945–0.979). The cut-off value above which H-FABP can be considered positive was found to be 17.7 ng/ml. Conclusion H-FABP is a promising biomarker for the early detection of patients with acute coronary syndrome.