Bioenergetic dysfunction and inflammation in Alzheimer's disease: a possible connection

• Published in: Frontiers in aging neuroscience Vol. 6; p. 311
• Main Authors: Wilkins, Heather M, Carl, Steven M, Greenlief, Alison C S, Festoff, Barry W, Swerdlow, Russell H
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 10.11.2014; Frontiers Media S.A
• Subjects: Acids; Alzheimer's disease; Antigens; Atherosclerosis; Bioenergetics; Chemokines; Cytokines; DAMP; Dementia; Genes; Inflammation; Mitochondria; Mitochondrial DNA; Neuroscience; Organelles; Polymorphism; Proteins; United States > US; Kansas City Missouri; Alzheimer’s disease; bioenergetics; inflammation; mitochondria; DAMP

Inflammation is observed in Alzheimer's disease (AD) subject brains. Inflammation-relevant genes are increasingly implicated in AD genetic studies, and inflammatory cytokines to some extent even function as peripheral biomarkers. What underlies AD inflammation is unclear, but no "foreign&q...