Bioenergetic dysfunction and inflammation in Alzheimer's disease: a possible connection

Inflammation is observed in Alzheimer's disease (AD) subject brains. Inflammation-relevant genes are increasingly implicated in AD genetic studies, and inflammatory cytokines to some extent even function as peripheral biomarkers. What underlies AD inflammation is unclear, but no "foreign&q...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in aging neuroscience Vol. 6; p. 311
Main Authors Wilkins, Heather M, Carl, Steven M, Greenlief, Alison C S, Festoff, Barry W, Swerdlow, Russell H
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 10.11.2014
Frontiers Media S.A
Subjects
Acids
Alzheimer's disease
Antigens
Atherosclerosis
Bioenergetics
Chemokines
Cytokines
DAMP
Dementia
Genes
Inflammation
Mitochondria
Mitochondrial DNA
Neuroscience
Organelles
Polymorphism
Proteins
United States > US
Kansas City Missouri
Alzheimer’s disease
bioenergetics
inflammation
mitochondria
DAMP
Online AccessGet full text

Cover

More Information
Summary:Inflammation is observed in Alzheimer's disease (AD) subject brains. Inflammation-relevant genes are increasingly implicated in AD genetic studies, and inflammatory cytokines to some extent even function as peripheral biomarkers. What underlies AD inflammation is unclear, but no "foreign" agent has been implicated. This suggests that internally produced damage-associated molecular pattern (DAMPs) molecules may drive inflammation in AD. A more complete characterization and understanding of AD-relevant DAMPs could advance our understanding of AD and suggest novel therapeutic strategies. In this review, we consider the possibility that mitochondria, intracellular organelles that resemble bacteria in many ways, trigger and maintain chronic inflammation in AD subjects. Data supporting the possible nexus between AD-associated bioenergetic dysfunction are discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Edited by: Elena Galea, Universitat Autònoma de Barcelona, Spain
Reviewed by: Changiz Geula, Northwestern University, USA; Gloria Patricia Cardona Gomez, University of Antioquia, Colombia
This article was submitted to the journal Frontiers in Aging Neuroscience.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2014.00311