Systemic absorption of gentamicin ear drops

Aminoglycoside-containing topical preparations are commonly used in the treatment of chronic suppurative otitis media and otitis externa. We report a case where systemic absorption of topical Gentisone HC occurred producing a serum gentamicin level of 6.2 micrograms/ml.

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Bibliographic Details
Published inJournal of laryngology and otology Vol. 111; no. 10; p. 960
Main Authors Green, K M, Lappin, D W, Curley, J W, de Carpentier, J P
Format Journal Article
LanguageEnglish
Published England 01.10.1997
Subjects
Absorption
Administration, Topical
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - therapeutic use
Gentamicins - blood
Gentamicins - pharmacokinetics
Gentamicins - therapeutic use
Humans
Kidney Failure, Chronic - blood
Male
Middle Aged
Otitis Media, Suppurative - blood
Otitis Media, Suppurative - drug therapy
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Summary:Aminoglycoside-containing topical preparations are commonly used in the treatment of chronic suppurative otitis media and otitis externa. We report a case where systemic absorption of topical Gentisone HC occurred producing a serum gentamicin level of 6.2 micrograms/ml.
ISSN:0022-2151
DOI:10.1017/S0022215100139076