Thrombophilias in pregnancy

• Published in: Hematology/oncology clinics of North America Vol. 25; no. 2; p. 323
• Main Authors: Battinelli, E M, Bauer, K A
• Format: Journal Article
• Language: English
• Published: United States 01.04.2011
• Subjects: Abortion, Spontaneous - blood; Abortion, Spontaneous - epidemiology; Abortion, Spontaneous - etiology; Abortion, Spontaneous - genetics; Abortion, Spontaneous - therapy; Abruptio Placentae - blood; Abruptio Placentae - epidemiology; Abruptio Placentae - etiology; Abruptio Placentae - genetics; Abruptio Placentae - therapy; Antiphospholipid Syndrome - complications; Antiphospholipid Syndrome - epidemiology; Antiphospholipid Syndrome - genetics; Antiphospholipid Syndrome - therapy; Factor V - analysis; Factor V - genetics; Female; Humans; Pre-Eclampsia - blood; Pre-Eclampsia - epidemiology; Pre-Eclampsia - etiology; Pre-Eclampsia - genetics; Pre-Eclampsia - therapy; Pregnancy; Pregnancy Complications, Hematologic - blood; Pregnancy Complications, Hematologic - epidemiology; Pregnancy Complications, Hematologic - genetics; Pregnancy Complications, Hematologic - therapy; Stillbirth - epidemiology; Stillbirth - genetics; Venous Thromboembolism - blood; Venous Thromboembolism - epidemiology; Venous Thromboembolism - etiology; Venous Thromboembolism - genetics; Venous Thromboembolism - therapy
• ISSN: 1558-1977
• DOI: 10.1016/j.hoc.2011.02.003

Thrombophilic conditions are associated with an increased risk of venous thromboembolic events (VTE) during pregnancy. Thrombophilic disorders are either acquired, as in antiphospholipid syndrome, or inherited, as in factor V Leiden. Both are associated with VTE but acquired disorders can also increase the risk of arterial events. However, there is controversy as to whether they may adversely affect other pregnancy outcomes including pregnancy loss, placental abruption, severe preeclampsia, and stillbirth. This article discusses the effect of thrombophilias on pregnancy.