Prospective characterization of the clinicopathologic and immunologic features of an immunodeficiency syndrome affecting juvenile llamas

• Published in: Veterinary immunology and immunopathology Vol. 49; no. 3; pp. 209 - 227
• Main Authors: Hutchison, J.M., Garry, F.B., Belknap, E.B., Getzy, D.M., Johnson, L.W., Ellis, R.P., Quackenbush, S.L., Rovnak, J., Hoover, E.A., Cockerell, G.L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.1995
• Subjects: Animals; Bacteremia - microbiology; Bacteria - isolation & purification; Bacterial Vaccines - administration & dosage; Bone Marrow - ultrastructure; Camelids, New World - immunology; Clostridium Infections - prevention & control; Clostridium Infections - veterinary; CLOSTRIDIUM PERFRINGENS; Clostridium perfringens - immunology; DEFICIENCE IMMUNOLOGIQUE; DEFICIENCIA INMUNOLOGICA; Female; Immunodeficiency; Immunoglobulin G - analysis; Immunologic Deficiency Syndromes - immunology; Immunologic Deficiency Syndromes - pathology; Immunologic Deficiency Syndromes - veterinary; IMMUNOLOGICAL DEFICIENCY; IMMUNOLOGIE; IMMUNOLOGY; INMUNOLOGIA; JLIDS; LAMA; LLAMA; LLAMAS; Lymph Nodes - ultrastructure; Lymphocyte Activation - immunology; Male; Opportunistic Infections - immunology; Opportunistic Infections - pathology; Opportunistic Infections - veterinary; Prospective Studies; STAPHYLOCOCCUS; Thymus Gland - ultrastructure; Toxoids - administration & dosage; Vaccination - veterinary; JLIDS; Immunology; Llama; Immunodeficiency
• ISSN: 0165-2427; 1873-2534
• DOI: 10.1016/0165-2427(95)05474-X

The clinicopathologic and immunologic features of 15 llamas affected with juvenile llama immunodeficiency syndrome (JLIDS) are described. Healthy adult ( n = 10) and juvenile ( n = 10) llamas served as controls. JLIDS llamas were characterized by wasting, and clinically apparent, repeated infections were frequently observed. The median age at which a health problem was first perceived was 11.6 months. All 15 affected llamas died or were killed, and JLIDS was confirmed at necropsy. The median duration of illness was 3.5 months. Lymphocyte blastogenesis assays showed suppressed responses (particularly to Staphylococcus sp. Protein A) in JLIDS llamas. No evidence of retroviral infection was detected. Mild, normocytic, normochromic, non-regenerative anemia, low serum albumin concentration and low to low-normal globulin concentrations were typically found on initial clinical evaluation. Lymph node biopsies showed areas of paracortical depletion. All llamas affected with JLIDS had low serum IgG concentrations, pre-vaccination titers against Clostridium perfringens C and D toxoids of ≤1:100, and no titer increase following vaccination.