Technical advances in studying cardiac electrophysiology – Role of rabbit models

Cardiovascular research has made a major contribution to an unprecedented 10 year increase in life expectancy during the last 50 years: most of this increase due to a decline in mortality from heart disease and stroke. The majority of the basic cardiovascular science discoveries, which have led to t...

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Published inProgress in biophysics and molecular biology Vol. 121; no. 2; pp. 97 - 109
Main Authors Kang, C., Brennan, J.A., Kuzmiak-Glancy, S., Garrott, K.E., Kay, M.W., Efimov, I.R.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.07.2016
Subjects
Action potential
Animals
Conduction velocity
Electrophysiology - methods
Heart - physiology
Heart Atria - metabolism
Heart Ventricles - metabolism
Humans
Models, Cardiovascular
NAD - metabolism
Optical mapping
Rabbits
Wavelength
Optical mapping
Action potential
Conduction velocity
Wavelength
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Summary:Cardiovascular research has made a major contribution to an unprecedented 10 year increase in life expectancy during the last 50 years: most of this increase due to a decline in mortality from heart disease and stroke. The majority of the basic cardiovascular science discoveries, which have led to this impressive extension of human life, came from investigations conducted in various small and large animal models, ranging from mouse to pig. The small animal models are currently popular because they are amenable to genetic engineering and are relatively inexpensive. The large animal models are favored at the translational stage of the investigation, as they are anatomically and physiologically more proximal to humans, and can be implanted with various devices; however, they are expensive and less amenable to genetic manipulations. With the advent of CRISPR genetic engineering technology and the advances in implantable bioelectronics, the large animal models will continue to advance. The rabbit model is particularly poised to become one of the most popular among the animal models that recapitulate human heart diseases. Here we review an array of the rabbit models of atrial and ventricular arrhythmias, as well as a range of the imaging and device technologies enabling these investigations.
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ISSN:0079-6107
1873-1732
DOI:10.1016/j.pbiomolbio.2016.05.006