Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19
The cytochrome P450 superfamily of mixed-function oxygenases has been extensively studied due to its many critical metabolic roles, and also because it is a fascinating example of gene family evolution. The cluster of genes on human chromosome 19 from the CYP2A, 2B, and 2F subfamilies has been previ...
Saved in:
| Published in | Pharmacogenetics (London) Vol. 11; no. 8; p. 687 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.11.2001
|
| Subjects | |
| Online Access | Get more information |
Cover
Loading…
| Abstract | The cytochrome P450 superfamily of mixed-function oxygenases has been extensively studied due to its many critical metabolic roles, and also because it is a fascinating example of gene family evolution. The cluster of genes on human chromosome 19 from the CYP2A, 2B, and 2F subfamilies has been previously described as having a complex organization and many pseudogenes. We describe the discovery of genes from three more CYP2 subfamilies inside the cluster, and assemble a complete map of the region. We comprehensively review the organization, structure, and expression of genes from all six subfamilies. A general hypothesis for the evolution of this complex gene cluster is also presented. |
|---|---|
| AbstractList | The cytochrome P450 superfamily of mixed-function oxygenases has been extensively studied due to its many critical metabolic roles, and also because it is a fascinating example of gene family evolution. The cluster of genes on human chromosome 19 from the CYP2A, 2B, and 2F subfamilies has been previously described as having a complex organization and many pseudogenes. We describe the discovery of genes from three more CYP2 subfamilies inside the cluster, and assemble a complete map of the region. We comprehensively review the organization, structure, and expression of genes from all six subfamilies. A general hypothesis for the evolution of this complex gene cluster is also presented. |
| Author | Hoffman, S M Keeney, D S Nelson, D R |
| Author_xml | – sequence: 1 givenname: S M surname: Hoffman fullname: Hoffman, S M email: hoffmasm@muohio.edu organization: Department of Zoology, Miami University, Oxford, OH 45056, USA. hoffmasm@muohio.edu – sequence: 2 givenname: D R surname: Nelson fullname: Nelson, D R – sequence: 3 givenname: D S surname: Keeney fullname: Keeney, D S |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11692077$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1j81OwzAQhH0ooj_wCsgPQGBtJ3F8RBV_UqVyoBKcKttZN0GJXTkJEjw9roC9rHa-1WhmSWY-eCSEMrhhoOQtpKkKyTIOwBhLV3aS5IwsQJWQCZa_zclyGD4SL4Tg52TOWKk4SLkgu208aN9-67EN_poOY5zsOEWk2tcUP0M3nQANjo4N0vX7C6cH9EhtNw0jRppYM_XaU9vE0Ich9EiZuiBnTncDXv7tFdk93L-un7LN9vF5fbfJbA5yzCpjrANpRMFrh0I4CUUJwlUpm1C2Nk4ApnYVU1ZWQuTo0h8rS5vXkheGr8jVr-9xMj3W-2Nsex2_9v_9-A8PnlNw |
| CitedBy_id | crossref_primary_10_1089_omi_2015_0104 crossref_primary_10_2217_14622416_8_7_743 crossref_primary_10_1016_j_mrfmmm_2004_05_007 crossref_primary_10_1369_jhc_4C6576_2005 crossref_primary_10_1016_j_abb_2004_03_016 crossref_primary_10_1016_j_heliyon_2024_e28952 crossref_primary_10_3389_fgene_2020_491895 crossref_primary_10_1016_j_dmpk_2018_01_001 crossref_primary_10_1097_00008571_200401000_00001 crossref_primary_10_1097_FPC_0b013e3283527c1c crossref_primary_10_1124_jpet_104_069872 crossref_primary_10_1517_17425250902865586 crossref_primary_10_1016_j_mrfmmm_2006_11_004 crossref_primary_10_1016_j_taap_2005_10_003 crossref_primary_10_1016_j_pharmthera_2012_12_007 crossref_primary_10_1074_jbc_M300319200 crossref_primary_10_1097_00008571_200211000_00007 crossref_primary_10_1373_clinchem_2004_031708 crossref_primary_10_1080_03602532_2020_1858856 crossref_primary_10_1016_S0169_409X_02_00065_0 crossref_primary_10_1124_dmd_109_027755 crossref_primary_10_1016_j_tox_2009_10_025 crossref_primary_10_1124_jpet_104_081570 crossref_primary_10_1007_s11033_009_9580_9 crossref_primary_10_1124_dmd_31_9_1081 crossref_primary_10_2147_PGPM_S379945 crossref_primary_10_2217_pgs_09_144 crossref_primary_10_1016_j_abb_2004_11_023 crossref_primary_10_1124_mol_104_008086 crossref_primary_10_1097_01213011_200512000_00004 crossref_primary_10_3109_00498251003713958 crossref_primary_10_1080_01926230601156286 crossref_primary_10_4028_www_scientific_net_AMR_926_930_1073 crossref_primary_10_1007_s00216_008_2291_6 crossref_primary_10_1016_j_biopsych_2006_10_005 crossref_primary_10_1016_j_yexmp_2014_10_012 crossref_primary_10_1081_DMR_120034149 crossref_primary_10_2217_14622416_9_11_1737 crossref_primary_10_1097_01_fpc_0000220560_59972_33 crossref_primary_10_1002_mnfr_202300239 crossref_primary_10_1080_03602530902843483 crossref_primary_10_2217_14622416_7_7_995 crossref_primary_10_1373_clinchem_2006_074856 crossref_primary_10_1016_j_taap_2003_09_020 crossref_primary_10_1186_1475_2875_13_420 crossref_primary_10_1007_s13277_013_0815_y crossref_primary_10_1186_1743_422X_6_20 crossref_primary_10_1016_S0027_5107_01_00274_3 crossref_primary_10_1124_molpharm_120_000100 crossref_primary_10_2217_pgs_15_156 crossref_primary_10_1016_j_cbi_2004_02_003 crossref_primary_10_2217_14622416_8_10_1385 crossref_primary_10_1146_annurev_pharmtox_43_100901_140251 crossref_primary_10_1007_s00228_004_0854_9 crossref_primary_10_1002_ijc_22136 crossref_primary_10_1371_journal_pone_0059556 crossref_primary_10_1016_j_ygeno_2008_01_004 crossref_primary_10_1007_s00277_010_1085_z crossref_primary_10_1007_s00439_019_02093_7 crossref_primary_10_1080_03014460_2017_1378368 crossref_primary_10_1124_jpet_302_2_416 crossref_primary_10_1016_j_bbrc_2005_08_190 crossref_primary_10_1038_nature02399 crossref_primary_10_4236_abc_2017_71005 crossref_primary_10_1097_FPC_0b013e3283540217 crossref_primary_10_1007_s00395_012_0319_8 crossref_primary_10_1071_RD11159 crossref_primary_10_1111_j_1462_5822_2007_01108_x crossref_primary_10_3390_ijms14048381 crossref_primary_10_51539_biotech_1182838 crossref_primary_10_2217_pgs_2018_0063 crossref_primary_10_1002_mgg3_1527 crossref_primary_10_1016_S0140_6736_03_13081_4 crossref_primary_10_1038_sj_clpt_6100246 crossref_primary_10_1097_01_fpc_0000189797_03845_90 crossref_primary_10_1016_j_taap_2004_12_027 crossref_primary_10_1016_j_cbpc_2019_108613 crossref_primary_10_1097_FTD_0b013e318058a4e0 crossref_primary_10_1124_dmd_112_048736 crossref_primary_10_3109_15412555_2016_1161017 crossref_primary_10_1124_jpet_107_133306 crossref_primary_10_1016_j_apsb_2016_07_016 crossref_primary_10_1007_s10709_007_9206_x crossref_primary_10_1097_MD_0000000000026614 crossref_primary_10_1097_FPC_0b013e3282ef5cd1 crossref_primary_10_1002_cpt_3124 crossref_primary_10_1002_humu_20698 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM |
| DOI | 10.1097/00008571-200111000-00007 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Biology Pharmacy, Therapeutics, & Pharmacology |
| ExternalDocumentID | 11692077 |
| Genre | Research Support, U.S. Gov't, P.H.S Journal Article Review |
| GrantInformation_xml | – fundername: NIAMS NIH HHS grantid: R01 AR45603 – fundername: NIAMS NIH HHS grantid: P30 AR41943 – fundername: NIGMS NIH HHS grantid: 1R15GM55951-01A1 |
| GroupedDBID | .Z2 123 4Q1 4Q2 4Q3 53G 5RE 5VS 8L- AAAAV AAIQE AAMTA AARTV AAYEP ABBUW ABDIG ABJNI ABXVJ ACDDN ACEWG ACGFS ACILI ACWDW ACWRI ACXNZ ADFPA ADGGA ADHPY ADNKB AE3 AEETU AFDTB AFUWQ AHQNM AHRYX AHVBC AINUH AJIOK AJNWD AJNYG AJZMW ALMA_UNASSIGNED_HOLDINGS AMJPA AMNEI AWKKM BQLVK BS7 C45 CAG CGR COF CS3 CUY CVF DIWNM DUNZO E.X EBS ECM EIF EJD EX3 F2K F2L F5P FL- IH2 IKREB IN~ JF9 JG8 JK3 JK8 K8S KD2 KMI NPM N~M OAG OAH OCUKA ODA OJAPA OL1 OLG OLV OLW OLZ OPC OPUJH ORVUJ OUVQU OVD OVDNE OWU OWV OWW OWX OWY OWZ OXXIT P-K R58 S4R S4S T8P TEORI VVN W3M WOQ WOW X3V X3W XXN XYM ZFV ZGI ZZMQN |
| ID | FETCH-LOGICAL-c407t-8bbcf07b352dfe33f705603f820739cdbf30e008819c78334efdfe166c4d725b2 |
| ISSN | 0960-314X |
| IngestDate | Tue Oct 15 23:25:32 EDT 2024 |
| IsPeerReviewed | false |
| IsScholarly | false |
| Issue | 8 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c407t-8bbcf07b352dfe33f705603f820739cdbf30e008819c78334efdfe166c4d725b2 |
| PMID | 11692077 |
| ParticipantIDs | pubmed_primary_11692077 |
| PublicationCentury | 2000 |
| PublicationDate | 2001-11-01 |
| PublicationDateYYYYMMDD | 2001-11-01 |
| PublicationDate_xml | – month: 11 year: 2001 text: 2001-11-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Pharmacogenetics (London) |
| PublicationTitleAlternate | Pharmacogenetics |
| PublicationYear | 2001 |
| SSID | ssj0015332 |
| Score | 1.533556 |
| SecondaryResourceType | review_article |
| Snippet | The cytochrome P450 superfamily of mixed-function oxygenases has been extensively studied due to its many critical metabolic roles, and also because it is a... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 687 |
| SubjectTerms | Animals Aryl Hydrocarbon Hydroxylases Chromosomes, Human, Pair 19 - genetics Cytochrome P-450 CYP2B6 Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - genetics Cytochrome P450 Family 2 Evolution, Molecular Gene Order Humans Multigene Family - genetics Oxidoreductases, N-Demethylating - chemistry Oxidoreductases, N-Demethylating - genetics Oxygenases - chemistry Oxygenases - genetics Steroid Hydroxylases - chemistry Steroid Hydroxylases - genetics |
| Title | Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19 |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/11692077 |
| Volume | 11 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT8MwDI54CIkLgvF-KQfEhRW1TZt0RzRAE4hph02CE1rSRBzYhsRAGr8eu0na8pKAS1U1a7fZXxPbsT8TcgQoyLmEN01nWR4kLTiTOmSBguUG1iuVxikWON90eWeQXN2mt1VAv6gumcpT9fZtXcl_tArXQK9YJfsHzZYPhQtwDvqFI2gYjr_Scb2QEmVlyWD9loB-dV_u8wDad70YWybrE_X4ggQJuFNgm_SpB0zLe56M9ImbW5zB2nPU1nhbwehcawFSxhA6E2N8JLUKr3a1Z4I8r9ISr8FvtlHycxd19SGHyNXe1WKHHCdvm1pZTqNRDS5ZbU7kdkX9MldbDmCbKiciVGyE_HVFoXv44RaQ-tOo0GEU8VYcil-MfmLR9kPzZF5k2OKji1Edt9sEJm-x2-T_lsv48uSe3_08JJt1j_zkkBSGSX-VrDiPgp5ZeKyROT1ukCXbY3TWIMdOg7Mm7Ve1ds9Nekx7FW35bJ0M6mhq0hJLFLBESyzRiaGAJYpYoggK6rBEYazAEq2wRKPWBhlcXvTbncA13QgU-PbTIJNSmVBIMMxzoxkzAkzkkBmwFAVrqVwaFmqQCViSSmSMJdrA5yLOVZKLOJXxJlkYT8Z6m9BMGJMLjYyEcTJUWiZ8CA5dzodcs6FId8iWFdz9k2VWufci3f1xZI8sV4jcJ4sGXmV9AHbhVB4WSn0H5VFaDQ |
| link.rule.ids | 780 |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Organization%2C+structure+and+evolution+of+the+CYP2+gene+cluster+on+human+chromosome+19&rft.jtitle=Pharmacogenetics+%28London%29&rft.au=Hoffman%2C+S+M&rft.au=Nelson%2C+D+R&rft.au=Keeney%2C+D+S&rft.date=2001-11-01&rft.issn=0960-314X&rft.volume=11&rft.issue=8&rft.spage=687&rft_id=info:doi/10.1097%2F00008571-200111000-00007&rft_id=info%3Apmid%2F11692077&rft_id=info%3Apmid%2F11692077&rft.externalDocID=11692077 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0960-314X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0960-314X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0960-314X&client=summon |