Safety and Efficacy of Etanercept Monotherapy for Moderate-to-severe Plaque Psoriasis：A Prospective 12-week Follow-up Study

• Published in: Current medical science Vol. 37; no. 6; pp. 943 - 947
• Main Author: 解方;王睿;赵梓纲;孟宪芙;林碧雯;杨洁;王文娟;丁香玉;杨怡;赵华;李承新;李恒进;周勇
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.12.2017; Department of Dermatology,Chinese PLA General Hospital,Medical College of Chinese PLA,Beijing100853,China%Department of Dermatology,Affiliated Hospital of Hebei United University,Medical College of Chinese PLA,Tangshan 063000,China
• Subjects: Medicine; Medicine & Public Health; plaque psoriasis; etanercept; efficacy
• ISSN: 1672-0733; 2096-5230; 1993-1352; 2523-899X
• DOI: 10.1007/s11596-017-1832-7

Etanercept has been shown to be effective for the treatment of moderate-to-severe plaque psoriasis. Since most clinical trials examined etanercept in combination with other drugs, the efficacy and safety of etanercept monotherapy for moderate-to-severe plaque psoriasis have not been well established. This prospective study enrolled 61 Chinese patients with moderate-to-severe plaque psoriasis to explore the efficacy and safety of etanercept monotherapy. These patients were treated with etanercept at a subcutaneous dose of 25 mg, twice a week, for 12 weeks. All the 61 patients completed the treatment and showed significant improvement in psoriasis area and severity index（PASI） scores. At 4, 8, and 12 weeks after treatment, the response rates（PASI75） were 0%, 21.31%, and 40.98%, respectively. It was concluded that etanercept monotherapy is efficacious and safe for patients with moderate-to-severe plaque psoriasis.