Laparoscopic versus open liver resection for hepatocellular carcinoma in elderly patients: Systematic review and meta-analysis of propensity-score matched studies

• Published in: International journal of surgery (London, England) Vol. 105; p. 106821
• Main Authors: Wang, Qian, Li, Hua-jian, Dai, Xiao-ming, Xiang, Zhi-qiang, Zhu, Zhu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.09.2022
• Subjects: Aged; Carcinoma, Hepatocellular; Hepatectomy - methods; Humans; Laparoscopy - adverse effects; Laparoscopy - methods; Length of Stay; Liver Neoplasms; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Postoperative Complications - surgery; Propensity Score; Retrospective Studies; Treatment Outcome
• ISSN: 1743-9191; 1743-9159; 1743-9159
• DOI: 10.1016/j.ijsu.2022.106821

The outcomes of elderly (≥65 years) patients with hepatocellular carcinoma (HCC) after laparoscopic liver resection (LLR) vs open liver resection (OLR) are debated. We compared the surgical and oncological outcomes after LLR and OLR in elderly HCC patients based on matched cohort studies that performed propensity score matching (PSM). A computer search of the PubMed, Embase, and Cochrane databases until January 31, 2022, was conducted using a combination of Medical Subject Heading (MeSH) terms and other terms. The Newcastle-Ottawa literature evaluation scale was used for quality assessment of the included studies that met the inclusion criteria and none of the exclusion criteria. The postoperative LLR and OLR markers after PSM were summarized. Seven matched cohort studies were included. There were 1346 patients after PSM, of which 673 (50%) underwent LLR and 673 (50%) underwent OLR. All studies were of high quality. For surgical outcomes, the length of surgery was longer in the LLR group than in the OLR group (RR = 29.47, 95% CI = 26.55–32.39, P < 0.00001), but the length of hospitalization was significantly shorter (RR = −1.05,95% CI = −1.24 to −0.86, P < 0.00001), and the incidence of total postoperative complications and severe complications were significantly fewer (RR = 0.69,95% CI = 0.60–0.79, P < 0.00001; RR = 0.49,95% CI = 0.35–0.71, P = 0.0001, respectively). There were no significant differences in overall survival or disease-free survival between the two groups (HR = 0.87, 95% CI = 0.63–1.21, P = 0.41; HR = 0.87, 95% CI = 0.69–1.08, P = 0.20, respectively). In elderly patients with HCC, LLR was associated with better surgical outcomes than OLR, but there was no significant difference in oncological outcomes. LLR should be the preferred surgical method for elderly patients with HCC. •Outcome of elderly patients with liver cancer after laparoscopic vs open liver resection is unclear.•We conducted a meta-analysis of propensity score matching studies to compare results of the two operations.•Length of hospitalization was shorter and frequency of complications was fewer with laparoscopic liver resection.•Overall survival and disease-free survival were similar with the two operations.