Intrinsic mechanism and pharmacologic treatments of noise-induced hearing loss

Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that have not been fully elucidated. The complex interaction between genetic and environmental factors, which influences numero...

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Bibliographic Details
Published inTheranostics Vol. 13; no. 11; pp. 3524 - 3549
Main Authors Xu, Ke, Xu, Baoying, Gu, Jiayi, Wang, Xueling, Yu, Dehong, Chen, Yu
Format Journal Article
LanguageEnglish
Published Australia Ivyspring International Publisher Pty Ltd 01.01.2023
Ivyspring International Publisher
Subjects
Alzheimer's disease
Cochlear implants
Drug Delivery Systems
Drug therapy
Ear, Inner
Eardrum
Hair
Hearing loss
Hearing Loss, Noise-Induced - drug therapy
Hearing Loss, Noise-Induced - genetics
Hearing protection
Homeostasis
Humans
Morphology
Neurotoxicity
Noise control
Pathogenesis
Review
Sound waves
drug delivery systems
noise-induced hearing loss
nanoparticles
pharmacologic strategies
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ISSN1838-7640
1838-7640
DOI10.7150/thno.83383

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Summary:Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that have not been fully elucidated. The complex interaction between genetic and environmental factors, which influences numerous downstream molecular and cellular events, contributes to the NIHL. In clinical settings, there are no effective therapeutic drugs other than steroids, which are the only treatment option for patients with NIHL. Therefore, the need for treatment of NIHL that is currently unmet, along with recent progress in our understanding of the underlying regulatory mechanisms, has led to a lot of new literatures focusing on this therapeutic field. The emergence of novel technologies that modify local drug delivery to the inner ear has led to the development of promising therapeutic approaches, which are currently under clinical investigation. In this comprehensive review, we focus on outlining and analyzing the basics and potential therapeutics of NIHL, as well as the application of biomaterials and nanomedicines in inner ear drug delivery. The objective of this review is to provide an incentive for NIHL's fundamental research and future clinical translation.
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Competing Interests: The authors have declared that no competing interest exists.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.83383