Gymnastics of Molecular Chaperones

Molecular chaperones assist folding processes and conformational changes in many proteins. In order to do so, they progress through complex conformational cycles themselves. In this review, I discuss the diverse conformational dynamics of the ATP-dependent chaperones of the Hsp60, Hsp70, Hsp90, and...

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Bibliographic Details
Published inMolecular cell Vol. 39; no. 3; pp. 321 - 331
Main Author Mayer, Matthias P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 13.08.2010
Subjects
Adenosine Triphosphate - genetics
Adenosine Triphosphate - metabolism
Animals
Heat-Shock Proteins - genetics
Heat-Shock Proteins - metabolism
Humans
Protein Conformation
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Summary:Molecular chaperones assist folding processes and conformational changes in many proteins. In order to do so, they progress through complex conformational cycles themselves. In this review, I discuss the diverse conformational dynamics of the ATP-dependent chaperones of the Hsp60, Hsp70, Hsp90, and Hsp100 families.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2010.07.012