A mild Theileria parva parasite with potential for immunisation against East Coast fever

• Published in: Veterinary parasitology Vol. 61; no. 1; pp. 41 - 47
• Main Authors: Mbogo, S.K., Kariuki, D.P., Ngumi, P.N., McHardy, N.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 1996
• Subjects: Animals; Antiprotozoal Agents - therapeutic use; BOVIN; CATTLE; Cattle-Protozoa; East Coast fever; GANADO BOVINO; IMMUNE RESPONSE; Immune response-Protozoa; IMMUNISATION; IMMUNIZATION; INMUNIZACION; Naphthoquinones - therapeutic use; Protozoan Vaccines; REPONSE IMMUNITAIRE; RESPUESTA INMUNOLOGICA; Stabilate; THEILERIA PARVA; Theileria parva - immunology; Theileria parva - isolation & purification; Theileriasis - immunology; Theileriasis - parasitology; Theileriasis - prevention & control; Time Factors; Immune response-Protozoa; East Coast fever; Stabilate; Theileria parva; Cattle-Protozoa
• ISSN: 0304-4017; 1873-2550
• DOI: 10.1016/0304-4017(95)00796-2

Twenty-three Friesian cattle were inoculated subcutaneously anterior to the left prescapular lymph node with 1 ml of a mild isolate of Theileria parva. The cattle developed low macroschizont parasitosis but no clinical reaction was observed. Thirty-five days later the cattle were grouped into five groups and challenged with five different Theileria parva isolates (four cattle-derived Theileria and one buffalo-derived Theileria). The cattle were all solidly immune to challenge with the cattle-derived Theileria isolates but three out of five of the cattle challenged with the buffalo-derived parasite died of theileriosis. All ten non-immunised control cattle developed severe theileriosis and were treated with buparvaquone (Butalex; Pitman-Moore).