Clinical Value of Serum Anti-Mullerian Hormone and Inhibin B in Prediction of Ovarian Response in Patients with Polycystic Ovary Syndrome

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 37; no. 1; pp. 70 - 73
• Main Author: 张帆 刘晓玲 荣楠 黄小文
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.02.2017; Department of Obstetrics and Gynecology,Affiliated Hospital of Jianghan University,Wuhan Sixth Hospital,Wuhan 430015,China%Department of Obstetrics and Gynecology,Guangdong Women and Children Hospital,Guangzhou 510010,China
• Subjects: Adult; Anti-Mullerian Hormone - blood; Estradiol - metabolism; Female; Follicle Stimulating Hormone - metabolism; Humans; Inhibins - blood; Luteinizing Hormone - metabolism; Medicine; Medicine & Public Health; Ovulation Induction - methods; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - metabolism; ROC Curve; Sensitivity and Specificity; Young Adult; 临床价值; 卵泡刺激素; 反应性; 多囊卵巢综合征; 患者; 血清; 酶联免疫吸附试验; 预测; inhibin B; anti-Mullerian hormone; polycystic ovary syndrome; ovarian response
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-017-1696-x

The present study aimed to investigate the clinical value of serum anti-mullerian hormone（AMH） and inhibin B（INHB） in predicting the ovarian response of patients with polycystic ovary syndrome（PCOS）. A total of 120 PCOS patients were enrolled and divided into three groups in terms of the ovarian response： a low-response group（n=36）, a normal-response group（n=44）, and a high-response group（n=40）. The serum AMH and INHB levels were measured by enzyme-linked immunosorbent assay（ELISA）. The follicle stimulating hormone（FSH）, luteinizing hormone（LH）, and estradiol（E2） levels were determined by chemiluminescence microparticle immunoassay. The correlation of the serum AMH and INHB levels with other indicators was analyzed. A receiver operating characteristic（ROC） curve was established to analyze the prediction of ovarian response by AMH and INHB. The results showed that there were significant differences in age, body mass index（BMI）, FSH, total gonadotropin-releasing hormone（Gn RH）, LH, E2, and antral follicle counts（AFCs） between the groups（P〈0.05）. The serum AMH and INHB levels were increased significantly with the ovarian response of PCOS patients increasing（P〈0.05）. The serum AMH and INHB levels were negatively correlated with the age, BMI, FSH level, Gn, and E2 levels（P〈0.05）. They were positively correlated with the LH levels and AFCs（P〈0.05）. ROC curve analysis of serum AMH and INHB in prediction of a low ovarian response showed that the area under the ROC curve（AUC） value of the serum AMH level was 0.817, with a cut-off value of 1.29 ng/m L. The sensitivity and specificity were 71.2% and 79.6%, respectively. The AUC value of serum INHB was 0.674, with a cut-off value of 38.65 ng/m L, and the sensitivity and specificity were 50.7% and 74.5%, respectively. ROC curve analysis showed when the serum AMH and INHB levels were used to predict a high ovarian response, the AUC value of the serum AMH level was 0.742, with a cut-off value of 2.84 ng/m L, and the sensitivity and specificity were 72.7% and 65.9%, respectively; the AUC value of the serum INHB level was 0.551 with a cut-off of 45.76 ng/m L, and the sensitivity and specificity were 76.3% and 40.2%, respectively. It was suggested the serum AMH and INHB levels have high clinical value in predicting the ovarian response of PCOS patients.