Cisplatin-albumin complex for treatment of cancer of the head and neck

Many patients with cancer of the head and neck are unable to receive or continue treatment with cisplatin, which is nephrotoxic, because of poor renal function. We present here, however, the case of a patient who underwent conventional cisplatin therapy but who then had to be withdrawn from treatmen...

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Bibliographic Details
Published inJournal of laryngology and otology Vol. 106; no. 9; p. 832
Main Authors Vreeburg, G C, Stell, P M, Holding, J D, Lindup, W E
Format Journal Article
LanguageEnglish
Published England 01.09.1992
Subjects
Aged
Albumins - administration & dosage
Cisplatin - administration & dosage
Cisplatin - adverse effects
Drug Combinations
Female
Humans
Kidney Diseases - chemically induced
Laryngeal Neoplasms - drug therapy
Neoplasm Recurrence, Local - drug therapy
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Summary:Many patients with cancer of the head and neck are unable to receive or continue treatment with cisplatin, which is nephrotoxic, because of poor renal function. We present here, however, the case of a patient who underwent conventional cisplatin therapy but who then had to be withdrawn from treatment because of renal toxicity despite having undergone partial remission. Treatment was then changed to cisplatin in the form of a cisplatin-albumin complex which is not nephrotoxic. The patient went on to a histologically confirmed complete response and we suggest that although the cisplatin-albumin complex may not be as effective as the conventional form of the drug it offers a possible form of treatment of patients with compromised renal function who could not otherwise be treated.
ISSN:0022-2151
DOI:10.1017/S0022215100121012