Increased susceptibility of erythrocytes to in vitro peroxidation in acute Trypanosoma brucei infection of mice
Trypanosoma brucei, Wamba strain, produced an acute infection in mice, and mortality was observed 2 days after the onset of parasitaemia which occurred 3–5 days postinfection. Anaemia was observed in the tail blood of the survivors. When washed erythrocytes from the heart blood were incubated in phy...
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Published in | Veterinary parasitology Vol. 55; no. 4; pp. 279 - 286 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.12.1994
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Subjects | |
Online Access | Get full text |
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Summary: | Trypanosoma brucei, Wamba strain, produced an acute infection in mice, and mortality was observed 2 days after the onset of parasitaemia which occurred 3–5 days postinfection. Anaemia was observed in the tail blood of the survivors. When washed erythrocytes from the heart blood were incubated in physiological saline containing 1.5% hydrogen peroxide, the erythrocytes of the infected mice produced significantly greater amounts of by-products of lipid peroxidation (measured as thiobarbituric acid reactive substances) than the erythrocytes of the control mice. This observation suggested that the infected mice may have a reduced ability in the prevention of free radical mediated lipid peroxidation in the erythrocyte membrane. It is concluded that peroxidative injury to the erythrocytes may contribute to the pathogenesis of anaemia in trypanosomosis. |
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Bibliography: | 9502864 L72 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0304-4017 1873-2550 |
DOI: | 10.1016/0304-4017(94)90070-1 |