Computer Aided Diagnosis for atrial fibrillation based on new artificial adaptive systems

• Published in: Computer methods and programs in biomedicine Vol. 191; p. 105401
• Main Authors: Buscema, Paolo Massimo, Grossi, Enzo, Massini, Giulia, Breda, Marco, Della Torre, Francesca
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.07.2020
• Subjects: Algorithms; Artificial Adaptive System; Artificial Neural Network; Atrial Fibrillation; Atrial Fibrillation - diagnosis; Computer Aided Diagnosis; Databases, Factual; Diagnosis, Computer-Assisted; Humans; Machine Learning; Supervised Contractive map; Supervised Contractive map; Artificial Adaptive System; Artificial Neural Network; Atrial Fibrillation; Computer Aided Diagnosis
• ISSN: 0169-2607; 1872-7565; 1872-7565
• DOI: 10.1016/j.cmpb.2020.105401

•A new methodology for AF diagnosis based on artificial adaptive systems is proposed.•Starting from the original ECG a process of progressive abstraction is performed.•AF is seen as a stable process managing the irregularity of irregularities of RR intervals.•A new methodology for data pre-processing based on progressive moving averages is proposed.•Automatic detection of Atrial Fibrillations for real world applications is possible. Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice, having been recognized as a true cardiovascular epidemic. In this paper, a new methodology for Computer Aided Diagnosis of AF based on a special kind of artificial adaptive systems has been developed. Following the extraction of data from the PhysioNet repository, a new dataset composed of the R/R distances of 73 patients was created. To avoid redundancy, the training set was created by randomly selecting 50% of the subjects from the entire sample, thus making a choice by patient and not by record. The remaining 50% of subjects were randomly split by records in testing and prediction sets. The original ECG data has been transformed according to the following four orders of abstraction: a) sequence of R/R intervals; b) composition of ECG data into a moving window; c) training of different machine learning systems to abstract the function governing the AF; d) fuzzy transformation of Machine learning estimations. In this paper, in parallel with the classic method of windowing, we propose a variant based on a system of progressive moving averages. The best performing machine learning, Supervised Contractive Map (SVCm), reached an overall mean accuracy of 95%. SVCm is a new deep neural network based on a different principle than the usual descending gradient. The minimization of the error occurs by means of decomposition into contracted sine functions. In this research, atrial fibrillation is considered from a completely different point of view than classical methods. It is seen as the stable process, i.e. the function, that manages the irregularity of the irregularities of the R/R intervals. The idea, therefore, is to abstract from mere physiology to investigate fibrillation as a mathematical object that handles irregularities. The attained results seem to open new perspectives for the use of potent artificial adaptive systems for the automatic detection of atrial fibrillation, with accuracy rates extremely promising for real world applications.