Evaluation of matrix metalloproteinase-9 expressions in nasopharyngeal carcinoma patients

• Published in: IOP conference series. Earth and environmental science Vol. 125; no. 1; pp. 12130 - 12133
• Main Authors: Farhat, Asnir, R A, Yudhistira, A, Daulay, E R, Puspitasari, D, Yulius, S
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.03.2018
• Subjects: Blood vessels; Cancer; Chemotherapy; Degradation; Extracellular matrix; Frequency distribution; Gelatinase B; Head & neck cancer; Histopathology; Immunohistochemistry; Lymphatic system; Matrix metalloproteinase; Matrix metalloproteinases; Metalloproteinase; Metastases; Nasopharyngeal carcinoma; Radiation therapy; Squamous cell carcinoma; Tissues; Tumor cells; Tumors; Vascularization
• ISSN: 1755-1307; 1755-1315
• DOI: 10.1088/1755-1315/125/1/012130

Nasopharyngeal carcinoma (NPC) is one of head and neck cancer with a poor prognosis because of the position of the tumor adjacent to the skull base and vital structures. Degradation of extracellular matrix that will cause tumor cells to invade surrounding tissues, vascular or lymphatic vessels. One that plays a role in the extracellular matrix degradation process is matrix metalloproteinase-9 (MMP-9). MMP-9 plays a role in tumor invasion process, metastasis and induction of tumor tissue vascularization. To determine the expression of MMP-9 in patients with nasopharyngeal carcinoma, a descriptive study was conducted by examining immunohistochemistry MMP-9 in 30 NPC tissues that had never received radiotherapy, chemotherapy or combination. Frequency distribution of NPC patient mostly in the age group 41-50 years old and 51-60 years were nine people (30.0%); men (73.3%) and non-keratinizing squamous cell carcinoma (53.3%) histopathology type. The overexpression of MMP-9 in patients with nasopharyngeal carcinoma were mostly found in advance stage.