Mesoporous silica nanoparticles with dual-targeting agricultural sources for enhanced cancer treatment via tritherapy

• Published in: RSC advances Vol. 13; no. 28; pp. 19079 - 19090
• Main Authors: Huang, Yu-Ya, Lee, Zui-Harng, Chang, Kai-Chi, Wu, Zhi-Yuan, Lee, Cheng-Chang, Tsou, Min-Hsuan, Lin, Hsiu-Mei
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 22.06.2023; The Royal Society of Chemistry
• Subjects: Bismuth; Cancer; Cancer therapies; Chemistry; Drug delivery systems; Folic acid; Gadolinium; Hyaluronic acid; Irradiation; Magnetic resonance imaging; Nanoparticles; Silicon dioxide; Survival; Toxicity
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/d3ra02068a

In this study, we introduced dual-targeting folic acid (FA) and hyaluronic acid (HA) modified on the surface of rice husk mesoporous silica nanoparticles (rMSNs). The rMSNs were employed as a drug delivery system loaded with camptothecin (CPT) as a model drug, Eu ions as a photosensitizer for photodynamic therapy (PDT), bismuth (Bi) for photothermal therapy (PTT), and Gd ions for magnetic resonance imaging (MRI) to develop novel nanoparticles, rMSN-EuGd-Bi@CPT-HA-FA, with dual-targeted function and triple therapy for cancer treatment. The results of the cell cytotoxicity experiment showed that the A549 cancer cells had a survival rate of approximately 35% when treated with 200 μg mL of rMSN-EuGd-Bi@CPT-HA-FA under 808 nm irradiation for 15 min. The dual-targeted function and synergistic treatment of CPT, PTT, and PDT were also responsible for the 20% survival rate of the A549 cancer cells treated with 200 μg mL of rMSN-EuGd-Bi@CPT-HA-FA under 808 nm irradiation for 30 min. The results showed that rMSN-EuGd-Bi@CPT-HA-FA can effectively combine chemotherapy (through CPT), PDT, and PTT for cancer treatment.