Suppression of protein adsorption on a graphene surface by phosphorylcholine functionalization

• Published in: Japanese Journal of Applied Physics Vol. 58; no. 5; pp. 55001 - 55004
• Main Authors: Taniguchi, Yoshiaki, Miki, Tsubasa, Ohno, Yasuhide, Nagase, Masao, Arakawa, Yukihiro, Imada, Yasushi, Minagawa, Keiji, Yasuzawa, Mikito
• Format: Journal Article
• Language: English
• Published: Tokyo IOP Publishing 01.05.2019; Japanese Journal of Applied Physics
• Subjects: Graphene; Phosphorylcholine; Protein adsorption; Proteins; Surface chemistry
• ISSN: 0021-4922; 1347-4065
• DOI: 10.7567/1347-4065/ab0b37

In this study, we examined phosphorylcholine (ChoP)-modified epitaxial graphene film based devices for the suppression of non-specific protein adsorptions onto a graphene surface. ChoP-pyrene derivatives were synthesized and immobilized on epitaxial graphene by the π-π stacking effect. The shifts in the transfer curve by protein adsorption were suppressed for the ChoP-modified graphene device, and this effect was independent of the charge and type of protein. In addition, the suppression effect was stable after 15 min of treatment with ultra-pure water owing to strong interactions of π electrons on the graphene surface. Consequently, our results indicate a stable blocking for protein adsorptions is achieved with an epochal ChoP derivative using robust bonding of a pyrene and a graphene film.