Role of gut microbiota in liver disease

The gut microbiome is the natural intestinal inhabitant that has been recognized recently as a major player in the maintenance of human health and the pathophysiology of many diseases. Those commensals produce metabolites that have various effects on host biological functions. Therefore, alterations...

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Published inAmerican journal of physiology: Gastrointestinal and liver physiology Vol. 318; no. 1; pp. G84 - G98
Main Authors Albhaisi, Somaya A. M., Bajaj, Jasmohan S., Sanyal, Arun J.
Format Journal Article
LanguageEnglish
Published United States 01.01.2020
Subjects
Animals
Bacteria - metabolism
Bacteria - pathogenicity
Disease Progression
Dysbiosis
Gastrointestinal Microbiome
Host-Pathogen Interactions
Humans
Intestines - microbiology
Liver - metabolism
Liver - pathology
Liver Diseases - metabolism
Liver Diseases - microbiology
Liver Diseases - pathology
Prognosis
Risk Factors
nonalcoholic steatohepatitis
alcoholic hepatitis
nonalcoholic fatty liver disease
bacteria
metagenomics
hepatocellular cancer
cirrhosis
gut microbiota
intestinal microbiome
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Summary:The gut microbiome is the natural intestinal inhabitant that has been recognized recently as a major player in the maintenance of human health and the pathophysiology of many diseases. Those commensals produce metabolites that have various effects on host biological functions. Therefore, alterations in the normal composition or diversity of microbiome have been implicated in various diseases, including liver cirrhosis and nonalcoholic fatty liver disease. Moreover, accumulating evidence suggests that progression of dysbiosis can be associated with worsening of liver disease. Here, we review the possible roles for gut microbiota in the development, progression, and complication of liver disease.
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ISSN:0193-1857
1522-1547
1522-1547
DOI:10.1152/ajpgi.00118.2019