Activation of the virion-associated RNA polymerase of vesicular stomatitis virus by melittin
Melittin, a major protein of bee venom, interacts with lipoprotein envelope of vesicular stomatitis virus. This interaction results in expression of the virion-associated transcriptase. The RNA synthetic properties of melittin-treated virions are similar to those previously observed with detergent-d...
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Published in | Biochemical and biophysical research communications Vol. 105; no. 4; pp. 1265 - 1271 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
29.04.1982
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Subjects | |
Online Access | Get full text |
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Summary: | Melittin, a major protein of bee venom, interacts with lipoprotein envelope of vesicular stomatitis virus. This interaction results in expression of the virion-associated transcriptase. The RNA synthetic properties of melittin-treated virions are similar to those previously observed with detergent-disrupted virions. In contrast to detergent-disruption melittin treatment does not affect the infectivity of the virions. Electron microscopic studies confirm that the melittin-disrupted virions maintain the native structure of the virus. |
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Bibliography: | 8225314 L73 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0006-291X 1090-2104 |
DOI: | 10.1016/0006-291X(82)90923-8 |