Toll-like Receptor Polymorphisms and Tuberculosis Susceptibility：A Comprehensive Meta-analysis

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 35; no. 2; pp. 157 - 168
• Main Author: 孙勤 张青 肖和平 白冲
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.04.2015; Clinic and Research Center of Tuberculosis, Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China%Clinic and Research Center of Tuberculosis, Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China%Department of Respiratory Diseases, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China; Department of Respiratory Diseases, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China
• Subjects: Female; Genetic Predisposition to Disease; Humans; Male; Medicine; Medicine & Public Health; Meta分析; Polymorphism, Genetic; TLR9; Toll-Like Receptors - genetics; Toll样受体; Tuberculosis - genetics; 国家知识基础设施; 基因多态性; 易感性; 结核病; meta-analysis; polymorphism; susceptibility; Toll-like receptor; tuberculosis
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-015-1405-6

The polymorphisms of toll-like receptor（TLR） have been hypothesized to affect the tuberculosis susceptibility. However, the direct evidence remains controversial. Here we performed a comprehensive meta-analysis to summarize the associations between TLR polymorphisms and tuberculosis susceptibility. We systematically searched the Pub Med, Embase, Cochrane library, and Chinese National Knowledge Infrastructure up to April 25, 2014. Case-control studies investigating TLR polymorphisms and tuberculosis susceptibility were included in the meta-analysis. Pooled odds ratios and corresponding 95% confidence intervals were calculated for cases and controls. Stata 11.0 and Review Manager 5.1 were adopted to conduct statistical analysis. We included 29 studies, involving 17 804 individuals. The results revealed an obvious increase of tuberculosis risk in TLR2 2258 AA, and decreased risk in TLR6 745 TT and TLR8 rs3761624 GA genotypes. Meanwhile, different genetic models were performed. TLR8 rs3764879 C, TLR8 rs3761624 A and TLR8 rs3764880 A alleles were associated with high susceptibility, while TLR6 745 T and TLR8 rs3788935 C alleles were protective. Other polymorphisms, including TLR9 1486C/T, did not show significant associations with tuberculosis infection. Finally, subgroup analysis in TLR8 rs3764880 according to gender found a slight elevated effect of A allele in males. The meta-analysis suggests significant associations between several TLR polymorphisms and tuberculosis, including TLR2 2258G/A, TLR6 745C/T, TLR8 rs3761624, TLR8 rs3764879, TLR8 rs3761624 and TLR8 rs3764880. This study serves as the framework for additional studies to determine further the role of TLRs in tuberculosis infection.