Measurement of relative cerebral blood volume using BOLD contrast and mild hypoxic hypoxia

Abstract Relative cerebral blood volume (CBV) was estimated using a mild hypoxic challenge in humans, combined with BOLD contrast gradient-echo imaging at 3 T. Subjects breathed 16% inspired oxygen, eliciting mild arterial desaturation. The fractional BOLD signal change induced by mild hypoxia is ex...

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Published inMagnetic resonance imaging Vol. 28; no. 8; pp. 1129 - 1134
Main Authors Wise, Richard G, Pattinson, Kyle T.S, Bulte, Daniel P, Rogers, Richard, Tracey, Irene, Matthews, Paul M, Jezzard, Peter
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.10.2010
Subjects
Adult
Blood Volume
BOLD
Brain - pathology
Brain Mapping - methods
Cerebral blood volume
Cerebral Cortex
Cerebrovascular Circulation
Female
fMRI
Humans
Hypoxia
Magnetic Resonance Imaging - methods
Male
Oxygen - chemistry
Perfusion
Radiology
Regression Analysis
fMRI
Hypoxia
Cerebral blood volume
BOLD
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Summary:Abstract Relative cerebral blood volume (CBV) was estimated using a mild hypoxic challenge in humans, combined with BOLD contrast gradient-echo imaging at 3 T. Subjects breathed 16% inspired oxygen, eliciting mild arterial desaturation. The fractional BOLD signal change induced by mild hypoxia is expected to be proportional to CBV under conditions in which there are negligible changes in cerebral perfusion. By comparing the regional BOLD signal changes arising with the transition between normoxia and mild hypoxia, we calculated CBV ratios of 1.5±0.2 (mean±S.D.) for cortical gray matter to white matter and 1.0±0.3 for cortical gray matter to deep gray matter.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0730-725X
1873-5894
DOI:10.1016/j.mri.2010.06.002