Enantioconvergent synthesis of chiral fluorenols from racemic secondary alcohols via Pd( ii )/chiral norbornene cooperative catalysis

An efficient protocol for the asymmetric synthesis of fluorenols has been developed through an enantioconvergent process enabled by Pd( ii )/chiral norbornene cooperative catalysis. This approach allows facile access to diverse functionalized chiral fluorenols with constantly excellent enantioselect...

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Published inChemical science (Cambridge) Vol. 15; no. 21; pp. 7975 - 7981
Main Authors Ding, Bo, Xue, Qilin, Wei, Han, Chen, Jiangwei, Liu, Ze-Shui, Cheng, Hong-Gang, Cong, Hengjiang, Tang, Jianting, Zhou, Qianghui
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 29.05.2024
Royal Society of Chemistry
The Royal Society of Chemistry
Subjects
Alcohols
Catalysis
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
Synthesis
FUNCTIONALIZATION
AMINATION
ENANTIOSELECTIVE SYNTHESIS
AMINES
DERACEMIZATION
ARYL IODIDES
DERACEMISATION
SELECTIVITY
CYCLIZATION
OXIDATIVE KINETIC RESOLUTION
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Summary:An efficient protocol for the asymmetric synthesis of fluorenols has been developed through an enantioconvergent process enabled by Pd( ii )/chiral norbornene cooperative catalysis. This approach allows facile access to diverse functionalized chiral fluorenols with constantly excellent enantioselectivities, applying readily available racemic secondary ortho -bromobenzyl alcohols and aryl iodides as the starting materials.
Bibliography:ObjectType-Article-1
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These authors contributed equally: Han Wei and Jiangwei Chen.
ISSN:2041-6520
2041-6539
DOI:10.1039/D4SC01004C