Herbo-mineral based Schiff base ligand and its metal complexes: Synthesis, characterization, catalytic potential and biological applications

• Published in: Journal of photochemistry and photobiology. B, Biology Vol. 160; pp. 163 - 171
• Main Authors: Kareem, Abdul, Laxmi, Arshad, Mohammad, Nami, Shahab A.A., Nishat, Nahid
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier B.V 01.07.2016
• Subjects: Anthelminthic activity; Anthelmintics - pharmacology; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Auxiliary ligand; Catalysis; Catalytic potential; Curcumin; Escherichia coli; Klebsiella pneumoniae; Ligands; Metals - chemistry; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Minerals - chemistry; Pheretima posthuma; Pseudomonas aeruginosa; Schiff base; Schiff Bases - chemistry; Schiff Bases - pharmacology; Spectrophotometry, Infrared; Staphylococcus aureus; Streptococcus pyogenes; X-Ray Diffraction; Schiff base; Curcumin; Catalytic potential; Auxiliary ligand; Anthelminthic activity
• ISSN: 1011-1344; 1873-2682
• DOI: 10.1016/j.jphotobiol.2016.03.030

Schiff base ligand, (L), derived from condensation reaction of 1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, (curcumin), with pyridine-3-carboxamide, (nicotinamide), and its complexes of Co(II), Ni(II) and Cu(II) ions, containing 1,10-phenanthroline as auxiliary ligand were synthesized and characterized by various physico-chemical techniques. From the micro analytical data, the stoichiometry of the complexes 1:1 (metal: ligand) was ascertained. The Co(II) and Cu(II) forms octahedral complexes, while the geometric structure around Ni(II) atom can be described as square planar. The catalytic potential of the metal complexes have been evaluated by recording the rate of decomposition of hydrogen peroxide. The results reveal that the percent decomposition of H2O2increases with time and the highest value (50.50%) was recorded for Co(II) complex. The ligand and its complexes were also screened for their in vitro antibacterial activity against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus pyogenes and Pseudomonas aeruginosa. The relative order of antibacterial activity against S. Pyogenes, S. aureus and E. coli is Cu(II)>Ni(II)>Co(II)>(L); while with P. aeruginosa, K. pneumoniae the order of activity is Cu(II)>Co(II)>Ni(II)>(L). The anthelmintic screening was performed using Pheretima posthuma. The order of anthelmintic activity of ligand and its complexes is [(Phen)CuLCl2]>[(Phen)CoLCl2]>[(Phen)NiL]Cl2>(L). [Display omitted] •Schiff base ligand derived from curcumin and its metal complexes•Characterization by various spectroscopic techniques•XRD and SEM images•Comparative study of catalytic potential of Co(II), Ni(II) and Cu(II) complexes•Antibacterial and anthelminthic study