Burdock miR8175 in diet improves insulin resistance induced by obesity in mice through food absorption

• Published in: iScience Vol. 27; no. 5; p. 109705
• Main Authors: Song, Huichen, Shi, Huanhuan, Ji, Mengru, Ding, Jiaqi, Cong, Lin, Chen, Silin, Zhou, Jiahui, Zha, Xinyan, Ye, Jinyang, Li, Runcheng, Hou, Xiaoyu, Mao, Siyu, Jiang, Xiaohong, Zhang, Wen, Li, Jing, Zhang, Yujing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.05.2024; Elsevier
• Subjects: Biological sciences; Cell biology; Molecular biology; Physiology; Cell biology; Biological sciences; Physiology; Molecular biology
• ISSN: 2589-0042; 2589-0042
• DOI: 10.1016/j.isci.2024.109705

The incidence of type 2 diabetes mellitus (T2DM) induced by obesity is rapidly increasing. Although there are many synthetic drugs for treating T2DM, they have various side effects. Here, we report that miR8175, a plant miRNA from burdock root, has effective antidiabetic activity. After administration of burdock decoction or synthetic miR8175 by gavage, both burdock decoction and miR8175 can significantly improve the impaired glucose metabolism of diabetic mice induced by a high-fat diet (HFD). Our results demonstrate that burdock decoction and miR8175 enhance the insulin sensitivity of the hepatic insulin signaling pathway by targeting Ptprf and Ptp1b, which may be the reason for the improvement in metabolism. This study provides a theoretical basis for the main active component and molecular mechanism of burdock to improve insulin resistance. And the study also suggests that plant miRNA may be an indispensable nutrient for maintaining human health. [Display omitted] •Burdock decoction improves insulin sensitivity in diet-induced obese mice•Burdock root contains abundant and stable miR8175•miR8175 can indeed improve insulin sensitivity in diet-induced obese mice•miR8175 improves insulin sensitivity by targeting Ptprf and Ptp1b Biological sciences; Physiology; Molecular biology; Cell biology