High-intensity interval training in people with Parkinson's disease: a randomized, controlled feasibility trial

• Published in: Clinical rehabilitation Vol. 33; no. 3; p. 428
• Main Authors: Harvey, Marguerite, Weston, Kathryn L, Gray, William K, O'Callaghan, Ailish, Oates, Lloyd L, Davidson, Richard, Walker, Richard W
• Format: Journal Article
• Language: English
• Published: England 01.03.2019
• Subjects: Aged; Aged, 80 and over; Feasibility Studies; Female; Heart Rate - physiology; High-Intensity Interval Training; Humans; Male; Middle Aged; Oxygen Consumption - physiology; Parkinson Disease - physiopathology; Parkinson Disease - rehabilitation; Walk Test; high-intensity interval training; exercise; physiotherapy; Parkinson’s disease
• ISSN: 1477-0873
• DOI: 10.1177/0269215518815221

To investigate whether people with Parkinson's disease can exercise at a high-intensity across a 12-week intervention and to assess the impact of the intervention on cardiorespiratory fitness. This is a randomized, controlled, feasibility study with waiting list control. Assessors were blinded to group allocation. The intervention took place at an exercise centre and assessments at a district general hospital. This study included 20 people with idiopathic Parkinson's disease. A total of 36 exercise sessions over 12 weeks, with each session lasting ~45 minutes, were conducted. The main measures were maximal heart rates achieved during exercise, recruitment rate, attendance, drop-out, change in peak oxygen consumption, cardiac output, cognitive function and quality of life. The study was considered technically feasible if participants achieved ⩾85% of maximal heart rate during exercise. There were 12 male and 8 female participants; they had a mean age of 68.5 years (standard deviation 6.825). Two participants were of Hoehn and Yahr stage I, 11 stage II and 7 stage III. In all, 17 participants completed the intervention. The median (interquartile range) proportion of repetitions delivered across the intervention which met our high-intensity criterion was 80% (67% to 84%). Mean peak heart rate was 88.8% of maximal. Peak oxygen consumption increased by 2.8 mL kg  min in the intervention group and 1.5 mL kg  min in the control group after 12 weeks of exercise. We estimate that a fully powered randomized controlled trial would require 30 participants per group. High-intensity interval exercise is feasible in people with Parkinson's disease. Improvements in cardiorespiratory function are promising.