Location of disulfide bridges in cardiotoxin from the venom of Formosan cobra (NAJA NAJA ATRA)

The location of the four disulfide bridges in cardiotoxin from the venom of the Formosan cobra, Naja naja atra, was determined by isolating cystine-containing peptides from the enzymic and partial acid hydrolyzates of the intact toxin. The results indicate that the disulfide bridges are formed by ha...

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Bibliographic Details
Published inInternational journal of peptide and protein research Vol. 11; no. 3; p. 229
Main Authors Narita, K, Cheng, K L, Chang, W C, Lo, T B
Format Journal Article
LanguageEnglish
Published Denmark 01.03.1978
Subjects
Amino Acid Sequence
Disulfides - analysis
Elapid Venoms - analysis
Elapid Venoms - pharmacology
Heart - drug effects
Humans
Taiwan
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Summary:The location of the four disulfide bridges in cardiotoxin from the venom of the Formosan cobra, Naja naja atra, was determined by isolating cystine-containing peptides from the enzymic and partial acid hydrolyzates of the intact toxin. The results indicate that the disulfide bridges are formed by half cystine residues 3--21, 14--38, 42--53, and 54--59. The amino acid sequence at the position 48--49 was revised to -Leu-Val- instead of Val-Leu- as reported previously.
ISSN:0367-8377
DOI:10.1111/j.1399-3011.1978.tb02843.x