Psoriasis and HLA-Cw6

The prevalence of histocompatibility antigen HLA-Cw6 was 72.7% in twenty-two patients with the guttate form and 45.9% in thirty-seven patients with the vulgaris form of psoriasis; the difference between these figures and the prevalence (7.4%) in 462 healthy blood donors in Finland is highly signific...

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Bibliographic Details
Published inBritish journal of dermatology (1951) Vol. 102; no. 2; p. 179
Main Authors Tiilikainen, A, Lassus, A, Karvonen, J, Vartiainen, P, Julin, M
Format Journal Article
LanguageEnglish
Published England 01.02.1980
Subjects
Finland
HLA Antigens - analysis
Humans
Psoriasis - genetics
Psoriasis - immunology
Finland
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Summary:The prevalence of histocompatibility antigen HLA-Cw6 was 72.7% in twenty-two patients with the guttate form and 45.9% in thirty-seven patients with the vulgaris form of psoriasis; the difference between these figures and the prevalence (7.4%) in 462 healthy blood donors in Finland is highly significant. The previously observed excess of several HLA-B locus genes might be secondary to their close linkage with the Cw6 gene. Hereditary factors appear more important in the guttate than in the vulgaris form of psoriasis.
ISSN:0007-0963
DOI:10.1111/j.1365-2133.1980.tb05690.x