Rapid leucine-enkephalin synthesis

Leucine-enkephalin, a naturally occurring pentapeptide with morphine-like activity, has been synthesized by a fragment condensation liquid phase method using 1,3,4-trimethyl-delta 3-phospholene-1,1-dichloride as a coupling agent. The advantages of this method are discussed.

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Bibliographic Details
Published inInternational journal of peptide and protein research Vol. 15; no. 1; p. 29
Main Authors Vilkas, E, Vilkas, M, Sainton, J
Format Journal Article
LanguageEnglish
Published Denmark 01.01.1980
Subjects
Amino Acid Sequence
Enkephalin, Leucine
Enkephalins - chemical synthesis
Indicators and Reagents
Methods
Organophosphorus Compounds
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Summary:Leucine-enkephalin, a naturally occurring pentapeptide with morphine-like activity, has been synthesized by a fragment condensation liquid phase method using 1,3,4-trimethyl-delta 3-phospholene-1,1-dichloride as a coupling agent. The advantages of this method are discussed.
ISSN:0367-8377
DOI:10.1111/j.1399-3011.1980.tb02546.x