Solid-phase synthesis: a paradigm shift

A personal review by the first graduate student of Professor R. Bruce Merrifield of the evolution of solid‐phase synthesis and its acceptance by various subsets of the chemistry community. Solid‐phase synthesis, as currently practised in the synthesis of biopolymers, combinatorial solid‐phase organi...

Full description

Saved in:
Bibliographic Details
Published inJournal of peptide science Vol. 9; no. 9; pp. 534 - 544
Main Author Marshall, Garland R.
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.09.2003
Subjects
combinatorial chemistry
Combinatorial Chemistry Techniques - history
Combinatorial Chemistry Techniques - instrumentation
Combinatorial Chemistry Techniques - methods
deletion sequences
History, 20th Century
History, 21st Century
John M. Stewart
Peptides - chemical synthesis
Peptides - chemistry
Peptides - history
R. Bruce Merrifield
solid-phase organic chemistry
solid-phase peptide chemistry
SPOC
SPPS
truncation
United States
United States
Online AccessGet full text

Cover

More Information
Summary:A personal review by the first graduate student of Professor R. Bruce Merrifield of the evolution of solid‐phase synthesis and its acceptance by various subsets of the chemistry community. Solid‐phase synthesis, as currently practised in the synthesis of biopolymers, combinatorial solid‐phase organic chemistry, synthesis of natural products, catalyst selection, chemical ligation and materials development, has proven a paradigm shift for the chemistry community. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.
Bibliography:ark:/67375/WNG-B1W7MDG0-D
istex:38B335982CABE48658C04CB67F0C41003DA7B613
ArticleID:PSC478
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Undefined-1
ObjectType-Feature-3
ISSN:1075-2617
1099-1387
DOI:10.1002/psc.478