Reperfused ischemia of the rat intestine: detection by MR imaging with polylysine-Gd-DTPA enhancement

• Published in: Magnetic resonance in medicine Vol. 35; no. 1; p. 131
• Main Authors: Mottet, I, Van Beers, B E, Delos, M, Goudemant, J F, Jamart, J, Demeure, R, Pringot, J
• Format: Journal Article
• Language: English
• Published: United States 01.01.1996
• Subjects: Animals; Contrast Media; Gadolinium DTPA; Gastrointestinal Hemorrhage - diagnosis; Gastrointestinal Hemorrhage - pathology; Intestinal Mucosa - blood supply; Intestinal Mucosa - pathology; Intestines - blood supply; Intestines - pathology; Ischemia - diagnosis; Ischemia - pathology; Magnetic Resonance Imaging - methods; Male; Organometallic Compounds; Pentetic Acid - analogs & derivatives; Polylysine; Rats; Rats, Wistar; Reperfusion Injury - diagnosis; Reperfusion Injury - pathology
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910350117

To detect reperfused ischemia of the rat intestine, T2-weighted spin-echo images were acquired, followed by T1-weighted images before and after administration of polylysine-Gd-DTPA or Gd-DTPA. Before administration of the contrast agent, the reperfused intestine was hyperintense on T2-weighted images, and to a lesser extent on T1-weighted images. After administration of polylysine-Gd-DTPA, the reperfused intestine enhanced more than the normal one, giving a significantly better contrast-to-noise (CNR) ratio than on unenhanced images. Gd-DTPA induced the same enhancement of the reperfused and the normal intestine and the CNR was lower than on unenhanced T2-weighted images. Reperfused intestinal ischemia could thus be better detected on polylysine-Gd-DTPA-enhanced MR images than on unenhanced images or on Gd-DTPA-enhanced images.