Adverse effects from the circadian fluctuations of carbamazepine plasma levels

In children on carbamazepine therapy who were complaining of tiredness it was proposed that the considerable plasma drug level variation over the day could explain this side effect. In spite of a "normal" fasting level the plasma drug level 2-4 hours after drug intake was well above the up...

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Bibliographic Details
Published inActa pædiatrica Scandinavica Vol. 72; no. 3; p. 397
Main Author Blennow, G
Format Journal Article
LanguageEnglish
Published Sweden 01.05.1983
Subjects
Adolescent
Carbamazepine - administration & dosage
Carbamazepine - adverse effects
Carbamazepine - blood
Child
Child, Preschool
Circadian Rhythm
Female
Humans
Male
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Summary:In children on carbamazepine therapy who were complaining of tiredness it was proposed that the considerable plasma drug level variation over the day could explain this side effect. In spite of a "normal" fasting level the plasma drug level 2-4 hours after drug intake was well above the upper recommended therapeutic level. It is recommended that the time of sampling should be taken into account in carbamazepine drug monitoring.
ISSN:0001-656X
DOI:10.1111/j.1651-2227.1983.tb09735.x