A simple procedure for obtaining high-quality NMR spectra of semiquantitative value from small tissue specimens: cervical biopsies

The handling of small tissue biopsy samples (< 100 microliters) for NMR investigations poses special problems. Optimal and stable positioning of the samples within the sensitive volume of the radiofrequency coil can be achieved by inserting the sample in a capillary. Methods for quantitation of t...

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Bibliographic Details
Published inMagnetic resonance in medicine Vol. 27; no. 2; p. 349
Main Authors Kuesel, A C, Kroft, T, Saunders, J K, Préfontaine, M, Mikhael, N, Smith, I C
Format Journal Article
LanguageEnglish
Published United States 01.10.1992
Subjects
Biopsy
Cervix Uteri - metabolism
Cervix Uteri - pathology
Equipment Design
Female
Humans
Magnetic Resonance Spectroscopy - instrumentation
Magnetic Resonance Spectroscopy - methods
Specimen Handling - instrumentation
Specimen Handling - methods
Uterine Cervical Diseases - diagnosis
Uterine Cervical Diseases - pathology
Uterine Cervical Neoplasms - diagnosis
Uterine Cervical Neoplasms - pathology
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Summary:The handling of small tissue biopsy samples (< 100 microliters) for NMR investigations poses special problems. Optimal and stable positioning of the samples within the sensitive volume of the radiofrequency coil can be achieved by inserting the sample in a capillary. Methods for quantitation of the spectral information from samples requiring histological evaluation after the NMR experiment are discussed, in particular with respect to cervical biopsies.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.1910270215