Regulation of flagellar length in Chlamydomonas

Chlamydomonas reinhardtii has two apically localized flagella that are maintained at an equal and appropriate length. Assembly and maintenance of flagella requires a microtubule-based transport system known as intraflagellar transport (IFT). During IFT, proteins destined for incorporation into or re...

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Published inSeminars in cell & developmental biology Vol. 19; no. 6; pp. 494 - 501
Main Authors Wilson, Nedra F., Iyer, Janaki Kannan, Buchheim, Julie A., Meek, William
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2008
Subjects
Animals
Biological Transport - physiology
Chlamydomonas
Chlamydomonas reinhardtii
Chlamydomonas reinhardtii - cytology
Chlamydomonas reinhardtii - genetics
Cilia
Flagella - ultrastructure
Flagellar length
Intraflagellar transport
Protozoan Proteins - genetics
Protozoan Proteins - metabolism
Signal transduction
Signal transduction
Intraflagellar transport
Chlamydomonas
Flagellar length
Cilia
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Summary:Chlamydomonas reinhardtii has two apically localized flagella that are maintained at an equal and appropriate length. Assembly and maintenance of flagella requires a microtubule-based transport system known as intraflagellar transport (IFT). During IFT, proteins destined for incorporation into or removal from a flagellum are carried along doublet microtubules via IFT particles. Regulation of IFT activity therefore is pivotal in determining the length of a flagellum. Reviewed is our current understanding of the role of IFT and signal transduction pathways in the regulation of flagellar length.
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ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2008.07.005